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Qualifications
BSc, BSc Hons & MSc (Wits), PhD (UCT)
Position
Pharmaceutical Chemistry - Head of Division
Contact information
Tel: +27 46 603 8397; Fax: +27 46 603 7506
Postal Address: Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Rhodes 老虎机游戏_pt老虎机-平台*官网, P O Box 94, Makhanda, 6140
Courier Address: 3rd Floor Office T6, Division of Pharmaceutical Chemistry, Faculty of Pharmacy, Artillery Roads, Rhodes 老虎机游戏_pt老虎机-平台*官网, Makhanda, 6140.
Email Address: s.khanye@ru.ac.za
Research
The focus of our Medicinal Chemistry Research Group at Rhodes 老虎机游戏_pt老虎机-平台*官网 is in the design and of new (chemical) bioactive compounds. The research group is situated in the Division of Pharmaceutical Chemistry, Faculty of Pharmacy, and it is part of Rhodes 老虎机游戏_pt老虎机-平台*官网 Centre for Chemico- and Biomedicinal Research. Our early drug discovery endeavours involved malaria (Prof Heinrich Hoppe – RU & Dr Dale Taylor – UCT), trypanosomes (Prof Heinrich Hoppe – RU), breast cancer (Prof Adrienne Edkins & Dr Jo-Anne de la Mare - RU), trichonomiasis (Prof Kirkwood Land – UP, USA), schistosomiasis (Prof Cornor Caffrey – UCSA, USA) and tuberculosis (TB – Prof Digby Warner – UCT).
Teaching
Selected publications
2019
[26] Anti-trypanosomal and anti-malarial properties of tetralone derivatives and structurally related benzocycloalkanones, Richard M. Beteck*, Lesetja J. Legoabe, Michelle Isaacs, Setshaba D. Khanye, Dustin Laming, Heinrich C. Hoppe. Medicina, 2019, 55, 206.
[25] New quinolone-based thiosemicarbazones showing activity against Plasmodium falciparum and Mycobacterium tuberculosis. Richard M. Beteck*, Ronnett Seldon, Audrey Jordaan, Digby F. Warner, Heinrich C. Hoppe, Dustin Laming, Michelle Isaacs, Setshaba D. Khanye*, Molecules, 2019, 24, 1740.
[24] Quinolone-isoniazid hybrids: Synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation, Richard M. Beteck, Ronnett Seldon, Audrey Joardaan, Digby F. Warner, Heinrich C. Hoppe, Dustin Laming, Lesetja Legoabe, Setshaba D. Khanye*, MedChemComm, 2019, 10, 326 – 331.
[23] Novobiocin-ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition, Mziyanda Mbaba*, Jo-Anne de la Mare, Jason N. Sterrenberg, Adrienne L. Edkins, Michelle Isaacs, Heinrich C. Hoppe, Setshaba D. Khanye*, Journal of Biological Inorganic Chemistry, 2019, 24, 139 – 149.
2018
[22] A novel synthesis method for tetraazatricyclic derivatives and evaluation of their biological properties. Felix Odame*, Richard Betz, Eric C. Hosten, Jason Krause, Michelle Isaacs, Heinrich C. Hoppe, Setshaba D. Khanye, Yasien Sayed, Carminita Frost, Kevin A Lobb, Zenixole R. Tshentu*, ChemistrySelect, 2018, 3, 13613 – 13618.
[21] Easy-to-synthesize spirocyclic compounds possess remarkable in vivo activity against Mycobacterium tuberculosis, Ana Guardia, Jessica Baiget, Mónica Cacho, Arancha Pérez, Montserrat Ortega-Guerra, Winston Nxumalo, Setshaba D. Khanye, Joaquín Rullas, Fátima Oertega, Elana Jiménez, Esther Pérez-Herrán, María Teresa Fraile-Gabaldón, Jorge Esquivias, Raquel Fernández, Esther Porras-De Francisco, Lourdes Encinas, Marta Alonso, Ilaria Giordano, Cristina Rivero, Juan Miguel-Siles, Javier G. Osende, Katrina A. Badiola, Peter J. Rutledge, Matthew H. Todd*, Modesto Remui?án, Carlos Alemparte*, Journal of Medicinal Chemistry, 2018, 61, 11327 – 11340.
[20] Synthesis, in vitro cytotoxicity and trypanosomal evaluation of novel 1,3,6-subsituted non-fluoroquinolones, Richard M. Beteck*, Michelle Isaacs, Heinrich C. Hoppe, Setshaba D. Khanye*, South African Journal of Chemistry, 2018, 71, 188 – 195.
[19] Synthesis, antiplasmodial and antitrypanosomal activity evaluation of a series of novel 2-oxoquinoline-based thiosemicarbazone derivatives, Oliver T. Darrell, Siyabonga T. Hulushe, Thanduxolo E. Mtshare, Richard M. Beteck, Michelle Isaacs, Dustin Laming, Heinrich C. Hoppe, Rui WM Krause, Setshaba D. Khanye*, South African Journal of Chemistry, 2018, 71, 174 – 181.
[18] Cinnammoyl-oxaborole amides: Synthesis and in vitro biological activity, Maureen Gumbo, Richard M. Beteck, Tawanda Mandizvo, Ronnett Seldon, Digby F. Warner, Michelle Isaacs, Heinrich C. Hoppe, Christiana C. Tan, Luisa W. Cheng, Nicole Liu, Kirkwood M. Land, Setshaba D. Khanye*, Molecules, 2018, 23, 2038 (1-13).
[17] Expanding the SAR of non-toxic antimalarial indolyl-3-ethanone ethers and thioethers, Mayibongwe J. Lunga, Ruramai L. Chissango, Carli Weyers, Michelle Isaacs, Dale Taylor, Setshaba D. Khanye, Heinrich C. Hoppe, Clinton G.L. Veale*, ChemMedChem, 2018, 13, 1353 – 1362.
[16] New thiazolidine-2,4-dione derivatives combined with organometallic ferrocene: Synthesis, structure and antiparasitic activity, Ogunyemi O. Oderinlo, Matshawandile Tukulula, Michelle Isaacs, Heinrich C. Hoppe, Vincent Smith, Setshaba D. Khanye*, Applied Organometallic Chemistry, 2018, 32, e4385.
2017
[15] Application of the Morita-Baylis-Hillman reaction in the synthesis of 3-[(N-cycloalkylbenzamido)methyl]-2-quinolones as potential HIV-1 integrase inhibitors, Khethobole C. Sekgota, Swarup Majumder, Michelle Isaacs, Dumisani Mnkandhla, Heinrich C. Hoppe, Setshaba D. Khanye, Frederik H. Kriel, Judy Coates and Perry T. Kaye*, Bioorganic Chemistry, 2017, 75, 310 – 316.
[14] Ferrocenyl and organic novobiocin derivatives: Synthesis and their biological activity, Mziyanda Mbaba, Amanda N. Mabhula, Natasha Boel, Adrienne L. Edkins, Michelle Isaacs, Heinrich C. Hoppe, Setshaba D. Khanye*, Journal of Inorganic Biochemistry, 2017, 172, 88 – 93.
[13] Unexpected transformations of 3-(bromoacetyl)coumarin providing new evidence for the mechanism of thiol mediated dehalogenation of a-halocarbonyls, Faith N. Magwezi, Setshaba D. Khanye, Clinton G.L. Veale*, Tetrahedron Letters, 2017, 58, 968 – 972.
2016
[12] Indolyl-3-ethanone-a-thioethers: A promising new class of non-toxic antimalarial agents, Archibale L. Svogie, Michelle Isaacs, Herinrich C. Hoppe, Setshaba D. Khanye, Clinton G.L. Veale*, European Journal of Medicinal Chemistry, 2016, 114, 79 – 88.
2015
[11] Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate. Clinton G.L. Veale*, Adrienne L. Edkins, Jo-Anne de la Mare, Peter Smith, Carmen de Kock, Peter J. Smith, Setshaba D. Khanye, Tetrahedron Letters, 2015, 56, 1860 – 1864.
[10] A ring-closing metathesis approach to eight-membered benzannelated scaffolds and subsequent internal alkene isomerizations. Abu Taher, Blessing A. Aderibigbe, Garreth L. Morgans, Lee G. Madeley, Setshaba D. Khanye, Leandi van der Westhuizen, Manuel A. Fernandes, Vincent J. Smith, Joseph P. Michael, Ivan R. Green, Willem A.L. van Otterlo*, Tetrahedron, 2013, 69, 2038-2047.
2004 - 2011
[9] Synthesis and in vitro antimalarial and antitubercular activity of gold(III) complexes containing thiosemicarbazone ligands, Setshaba D. Khanye, B. Wan, S.G. Franzblau, Jiri Gut, Philip J. Rosenthal, Gregory S. Smith*, Kelly Chibale*, Journal of Organometallic Chemistry, 2011, 696, 3392 – 3396.
[8] Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity. Setshaba D. Khanye, Jiri Gut, Philip J. Rosenthal, Kelly Chibale*, Gregory S. Smith*, Journal of Organometallic Chemistry, 2011, 696, 3296-3300.
[7] Gold(I) derived thiosemicarbazone complexes with rare halogen-halogen interaction – reduction of [Au(damp-C1,N)Cl2]. Setshaba D. Khanye, Nikoletta B. Báthori, Gregory S. Smith, Kelly Chibale*, Dalton Transactions, 2010, 39, 2697-2700. JIF = 3.93
[6] Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity. Setshaba D. Khanye, Gregory S. Smith, Carmen Lategan, Peter J. Smith, Jiri Gut, Philip J. Rosenthal, Kelly Chibale*, Journal of Inorganic Biochemistry, 2010, 104, 1079-1083.
[5] Synthesis of unsaturated 1,4-heretoatom-containing benzo-fused heterocycles using a sequential isomerisation-ring-closing metathesis strategy. Garreth L. Morgans, E. Lindani Ngidi, Lee G. Madeley, Setshaba D. Khanye, Joseph P. Michael, Charles B. de Koning, Willem A.L. van Otterlo*, Tetrahedron, 2009, 65, 10650-10659.
[4] Butyldiphenylphosphine oxide. Judy Caddy*, E. Mabel Coyanis, Andreas Lemmerer, Setshaba D. Khanye, Bernardi Omondi, Acta Crystallographica Section E, 2007, E63, o1032-o1033.
[3] Cis-ethylenebis(diphenylphosphine oxide). Judy Caddy*, E. Mabel Coyanis, Manuel A. Fernandes, Setshaba D. Khanye, Bernard Omondi, Acta Crystallographica Section E, 2007, E63, o1387-o1389.
[2] Gold(I) complexes of 1,2-bis(butylphenylphosphino)ethane and cis-1,2-bis(butylphenylphosphino)ethylene. Setshaba D. Khanye, Judy Caddy, Marcus Layh*, Gold Bulletin, 2007, 40, 45-51.
[1] Isomerization and ring-closing metathesis for the synthesis of 6-,7- and 8-membered benzo- and pyrido-fused N,N-, N,O- and N,S-heterocycles. Willem A.L. van Otterlo*, Garreth L. Morgans, Setshaba D. Khanye, Blessing A.A. Aderibigbe, Joseph P. Michael, David G. Billing, Tetrahedron Letters, 2004, 45, 9171-9175.
Awards and grants
Web presence
Google Scholar
https://scholar.google.co.za/citations?hl=en&user=wRNt99gAAAAJ
Orcid ID
https://orcid.org/0000-0003-0725-5738
Research Gate
https://www.researchgate.net/profile/David_Khanye
Recent former students
Students highlighted with an asterisk (*) indicate where my involvement has been as a co-supervisor.
MSc students - completed
PhD students - completed
Current students
Postdoctoral fellow
Professional affiliations
2009 – Present Member of South African Chemical Institute
2014 – Present Member of Rhodes Centre for Chemico- and Biomedicinal Research
Last Modified: Thu, 28 Jan 2021 01:45:18 SAST